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We see no reason why the GigaAssay cannot be applied to other genes and assays to address other important questions in biomedical sciences. We identify a pattern in Tat where PPIs and PTMs are selected for robustness, while key structural elements or ...

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"Fig. 2 and Supplementary Fig. S18E https://www.researchsquare.com/article/rs-708936/v1 reveals previously unrecognized limitations of truncation mutant studies. The context also produces a framework to identify ambiguities and potential misinterpretation of mutant data regarding ...

We have mapped out 95% of Variants and their functional effect on the cell for ERBB2.
You have a drug Trastuzumab that binds to ERBB2.
If we put the two together in our experiment we could help you. [email protected]

#ERBB2 #Drugtrial

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1,300 square feet at [email protected]’ satellite location at 833 Las Vegas Blvd. North (former Library) is where Heligenics now stand. The [email protected] at 300 S. 4th Street, which opened in September 2019, is fully occupied with ten tenants, prompting the city to expand its ...

Modernize your clinical trials today at http://Heligenics.com and download our Superprecsion Clinical Trial Success PDF file, exclusively made for you.

#PrecisionClinicalTrial #ModernizeDrugs

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Every time someone takes a #drug, they know in advance their individual #mutations will not cause any side effects from that particular drug.

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GigaAssay results create a context to improve interpretation with a new structure/function/tolerance approach. Herein, alanine scanning (Fig. 2, Supplementary Fig. S3D link: https://www.researchsquare.com/article/rs-708936/v1) identifies .....

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Phage or yeast display, yeast 1- or 2-hybrid, DNA encoded libraries (DEL)s, and affinity mass spectrometry assess one general type of function, molecular interactions, although these interactions are not assessed in living mammalian cells.3–6 More recently, lethality ...

Heligenics comprehensively measures the functional significance of all mutations in a gene coding region through a combination of saturating mutagenesis and a massively parallelized assay called the GigaAssay. We are the sole-source provider for this service
#Mutagenesis

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Problem:
There is no high-throughput #assay to broadly assess molecular functions in the context of human or #MammalianCells. The molecular function are the key to understanding mechanism, disease etiology, and development of therapeutic #drugs.
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The GigaAssay has several other advantages over previously developed high throughput assays and screens (Supplementary Table S1).

Heligenics' GeneMutation Functional Libraries meet 4 needs at many stages of the DrugDevelopment pipeline in the PharmaceuticalIndustry:
✅Preclinical drug evaluation.
✅ Superprecision clinical trials.
✅Rescuing failed drugs in a clinical trial. 
✅Identify Off-target receptors