Our GigaAssay Technology

A massively parallelized platform for assaying molecular functions

Single cell assaying without the need for mechanical separation

The GigaAssay is a massively parallelized platform for assaying molecular functions of single cells in culture without the need for mechanical separation of the cells.

Heligenics Inc. was formed to implement the GigaAssay to produce saturating mutation/function maps for key genes already established for both inherited disease and cancer diagnostics, or associated with actionable therapies.

The GigaAssay technology was developed at the University of Nevada Las Vegas in the Schiller Laboratory of Applied Bioinformatics. As a massively parallel biological assay that can simultaneously measure how millions of genetic variants or other sequence variables affect the molecular function of cell process, this would take many years if not decades to accomplish using conventional methods. To date, there are no other established assays that assess cell processes and molecular functions in human cells at this kind of scale.

Comparison of the GigaAssay to alternative technologies and databases

ClinVar is the United States National Institutes of Health effort to develop a clinical database to connect human variation encountered in clinical genetic testing with supporting evidence of phenotypes.

Myriad Genetics is a for-profit company that since 1996 had a monopoly on BRCA testing until 2013 when it was struck down by the US Supreme Court. They continue to maintain their own proprietary database of BRCA1/2 variants with over 17,000 variants cataloged. Their database has variants only for BRCA1/2 and a few other hereditary risk genes for breast cancer.

Below is a table comparing the highly parallel GigaAssay to several potential alternative techniques and databases.

Feature GigaAssay Academic Phage Disp. ClinVar db Myriad db
Assay >1,000,000 variants simultaneously
Measure molecular function & cellular processes
Assay in mammalian cells or entire organism
Measure protein binding in vivo
Standardized assay for variants
Assess SNP dyad haplotypes
Does not require cell manipulation
Commercialized
Used for genetic testing or drug development

Most clinical applications use one mutation that is correlated to an outcome

With Heligenics you measure how 10,000 mutations cause an outcome

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