The structure for Brivanib complexed with a receptor was not available but there is a structure with another ATP analog, AAL993 that binds VEGFR2 (PDB: 5EW3). The contact residues for the drug with the binding site are: V848, A866, V867, K868, I892, E885, I888, L889, V898, V914, V916, E917, C919, L1019, L1035, I1044, D1046, F1047.
There are no mutations in VEGFR2 for hepatocellular cancer and only 17 variants for other disorders in ClinVar, the main public disease-variant database. However, there are 713 missense variants observed in ~250,000 people ranging from singletons to 22% allele frequency; 74 variants are in the drug binding site region. There are about 1,500 missense variants observed in cancers (COSMIC), with approximately 100 in this binding site region.