Discovering Whole Gene Biomarkers

Accurately diagnose which mutations are causing a disease

Whole Gene Biomarkers PDF

Accurate diagnostics with precision biomarker gene panels

Genetic biomarkers are particularly useful for oncology therapeutics. However, most approved drugs have a single variant biomarker. Heligenics offers whole gene biomarkers, where all variants with similar activity to an established biomarker can be used.

Five Facts

  • Steady growth in genetic biomarkers over the last decade
  • There are 100s of genetic biomarkers
  • Genes have many variants with the same activity of known biomarkers
  • Whole gene markers expand the number of customers for a drug
  • one size doesn’t fit all

Treatments based on one genetic marker have medical advantages

Emergence of Genetic Biomarkers

 •   46% of total recent approvals

•    One mutation as a biomarker

From “The Personalized Medicine Report: 2017 Opportunity, Challenges, and the Future”.

Whole Gene Biomarker

Example of patients with single mutation biomarker identified versus using GML whole gene biomarker panel

Single Mutation Biomarker

GML Whole Gene Biomarker

Disease, but lack Single
Mutation Biomarker

Disease with Single Mutation

Disease with Whole Gene

One Size Does Not Fit All

Percentage of the patient population for which a particular drug is NOT effective


Asthma Drugs

Diabetes Drugs

Arthritis Drugs

Alsheimer’s Drugs

Cancer Drugs







From Spear and Huff et al. Trends Mol Med 2001 Clinical application of pharmacogenetics.

“Precision” cancer therapeutics are based on a single genetic mutation

Heligenics whole gene biomarkers utilize the complete gene

Failed clinical trial – rescue an FDA rejection with whole gene biomarkers

Whole gene biomarkers examine all the mutations in a gene rather than a single mutation. This is a natural conceptual expansion of what is already being done.

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