Developing New Drugs

Preclinical evaluation leads and derivatives for potential resistance

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New Drugs PDF

Preclinical evaluation for drug resistance

All large pharmaceutical companies assume high risk in attempts to bring drugs to market. More and more can be outsourced to reduce failure risk before the expensive clinical trial. Don’t send a compound into trials blind. Our Gene Mutation Libraries (GMLs) have several applications in the preclinical drug development pipeline: evaluating lead compounds and derivatives and characterizing compounds ready for trials. GMLs from cells treated with and without drugs can identify mutations in binding pockets that are likely to affect efficacy. Comparison to common and disease variants can also guide the selection of compounds for clinical testing.

Why not minimize safety and efficacy concerns before an expensive time-consuming trial?

Five Facts

  • Identify amino acid positions and genetic variants of concern for safety – dose-response/toxicity
  • Eliminate adverse events and non-responders before an expensive clinical trial
  • Identify minimum effective doses stratified by common genetic variants – time course/dose-response
  • Guide drug derivatization with GMLs by identifying amino acid substitutions near the drug binding site that impact function and will likely impact the efficacy
  • Get more drugs approved

Modernize your preclinical drug development pipeline with GMLs

Spend $100Ms on a trial to discover unforeseen poor efficacy, or

let Heligenics help weed out resistant participants before the trial

Every drug company needs to do this before investing in a clinical trial

The Test You Didn’t Know Existed

Modernize your drug development approach by taking advantage of cutting-edge functional genomics with Gene Mutation/Function Libraries (GMLs). Through a massively parallel mammalian cell in vivo process called the GigaAssay, Heligenics produces what is called a Gene Mutation/Function Library (GMLs). Each GML measures the impact of all possible amino acid substitutions in the target upon its molecular function in live human cells. GMLs have several applications in the drug development pipeline: screening lead compounds, evaluating derivatives, characterizing compounds ready for trials, and optimizing trial design for approval.

These are the major factors that produce a much higher risk for the drug development and approval process.

Super-precision Clinical Trials

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